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Clinical Research
Mission: To improve pediatric surgical practice through the application of principles of evidence-based research.
Goals:
- To conduct multi-center randomized clinical trials.
- To develop multi-center databases to document clinical practice patterns and patient outcomes.
- To observe and characterize the pediatric surgery work environment and create solutions for improvement.
- To document pediatric surgical outcomes using novel medical informatics tools.
- To integrate research findings into current clinical practice.
Click here for a list of completed projects
Ongoing Projects
Perforated Necrotizing Enterocolitis in the Premature Neonate
Multi-center
randomized clinical trial comparing laparotomy vs peritoneal drainage for
perforated Necrotizing Enterocolitis.
Principal Investigator: R. Lawrence Moss, MD
Lead Investigator: Bonnie Lang Silverman, PhD
Co-investigators: Richard Ehrenkranz, MD; Perry Miller, MD, PhD; Cynthia A Brandt, MD, MPH
Glaser Pediatric Research Network (GPRN) Neonatal Surgical Database:
Necrotizing Enterocolitis (NEC) Protocol (A Glaser Pediatric Research Network Study; Sponsored by the Elizabeth Glaser Pediatric Research Foundation; Supported by the Gerber Foundation)
Multi-center
observational prospective database to identify outcome trends and risk factors
for progression of NEC.
Principal Investigator: R. Lawrence Moss, MD
Lead Investigator: Bonnie Lang Silverman, PhD
Co-investigator: Richard Ehrenkranz, MD
Pediatric Trauma Radiation Dose Study
Historical cohort study to review clinical status, radiology studies and outcomes of children admitted with trauma
Principal Investigator: Milissa McKee, MD, MPH
Lead Investigator: Karen A. Diefenbach, MD
Clinical Epidemiologist: Bonnie Lang Silverman, PhD
Investigator: R. Lawrence Moss, MD
Risk Factors for Necrotizing Entercolitis
Totalis
Nested case control study to determine whether feeding regimen is associated with NEC Totalis and whether there are clinical changes which predict the onset of this disease
Principal Investigator: Bonnie Lang Silverman, PhD
Investigator: Karen A. Diefenbach, MD
Investigator: Marion C. W. Henry, MD, MPH
Investigator: R. Lawrence Moss, MD
Association Between Intra-abdominal Pressure
and Necrotizing Enterocolitis
Prospective feasibility study determine if there is a correlation between intra-abdominal pressures and severity of disease in premature infants with necrotizing enterocolitis.
Principal Investigator: Karen A. Diefenbach, MD
Investigator: R. Lawrence Moss, MD
Clinical Epidemiologist: Bonnie Lang Silverman, PhD
National Surgical Quality Improvement
Program (NSQIP). American College of
Surgeons, Development of a Pediatric Surgical Program within the
American College of Surgeons, National Surgical Quality Improvement Program
(NSQIP)
Principal Investigator: R. Lawrence Moss, MD
